Consistent with the higher incidence of MM among individuals of African or African-American ancestry, we observed the highest polygenic risk scores in the AMR super-populations (Supplementary Fig. 4; median 2.24 relative to our study population), due to a higher prevalence of several risk alleles (e.g., 3p22.1/ULK4, 16p11.2/RNF40, 10q24.33/STN1, 19p13.3/NFIC, and 2p23.3/DTNB-AS1; Supplementary Data 8). The gene discussed is RNF40; the disease is Miyoshi myopathy.