MM can be classified into hyperdiploid and non-hyperdiploid subtypes, the latter being primarily composed of cases with immunoglobulin heavy-chain (IGH) translocations, t(11;14), t(4;14) and t(14;16), which lead to over-expression of oncogenes, CCND1, MMSET and MAF respectively, through juxtaposition with the IGH locus. Here, CCND1 is linked to Miyoshi myopathy.