Several of these were further supported by DepMap essentiality in MM or lymphoid cells (Supplementary Data 11), a Mendelian cancer predisposition syndrome (BRCA2, CDKN2A, POT1, and RFWD3)15,16, a congenital B-cell immunodeficiency (TNFRSF13B and WAC)17,18, or recurrent somatic genetic lesions in MM (IRF4, MYC, PRDM1, JARID2, MXI1, TNFRSF13B, and POT1)19–23. This evidence concerns the gene RFWD3 and Miyoshi myopathy.