TMPRSS2 and neoplasm: Accordingly, the patient, PDX, and UCDCaP cells contained mutations in critical genes such as AR (missense, deletion), ATM, BRCA1, CHD4, ERBB2, PIK3CA, TMPRSS2, TP53, TSC1/2, and XPA (frameshift) (Supplementary Fig. 1b), again underscoring the relevance and fidelity of the UCDCaP cell line model in preserving the genetic landscape of the original patient tumor.