Matrix metalloproteinase-12 (MMP-12) was markedly increased in patients with OSMF compared with other healthy individuals, salivary C-reactive protein (CRP) levels were increased in malignant conditions or OSMF patients, fibrinogen-producing factor (FPF) could indicate an increase in saliva levels in OSMF patients. This evidence concerns the gene MMP12 and oral submucous fibrosis.