Since COVID-19 mRNA vaccines, including Pfizer and Moderna, express S protein antigen by delivering SARS-2-S mRNA, we next asked whether SARS-2-SWT and S-protein-based vaccine (SARS-2-SV) delivered in the form of encoding mRNA would trigger syncytium formation and cell senescence (S3A Fig). The gene discussed is PROS1; the disease is COVID-19.