PLXNA3 and hypogonadism: In contrast, the prevalence of hypogonadism in this study was lower than in studies conducted in ‘Brazil 37.5% [18], India 39.5% [19], Indonesia 40.6% [20], and Turkey 51% [8], this discrepancy might be due to many factors-: All of these studies didn’t use the current definition of hypogonadism stated by International Society For the Study of Aging Male (ISSAM), which includes sex hormone level and symptoms of hypogonadism together, and in some studies, the cut-off point for low testosterone was not stated.