A 2024 retrospective analysis by Pallud et al. of IDH1-wildtype GBM yielded similar findings regarding the prognostic impact of seizure presence at disease presentation; we add to this analysis by also reporting a previously undescribed significant increase in both overall and progression-free survival among patients whose first seizure occurred after histologically-confirmed diagnosis of HGG (our “Late Seizure” group) [15]. This evidence concerns the gene IDH1 and glioblastoma.