Notably, inhibition of β1 integrin or hERG1 activity reduced AKT phosphorylation and E4301 abrogated the protective effect of BM-MSC coculture on B-ALL chemosensitivity, providing further support for the contribution of the hERG1/β1 integrin complex in adhesion-mediated chemoresistance. Here, AKT1 is linked to precursor B-cell acute lymphoblastic leukemia.