The formation of a membrane-bound complex containing the β1 integrin, CXCR4 and the human ether-a-go-go-related gene (hERG) potassium channel, on the surface of B-ALL cells following B-ALL/BM-MSC interactions, contributes to chemoresistance [57]. Here, KCNH2 is linked to precursor B-cell acute lymphoblastic leukemia.