Our GeoMx WTA also showed enrichment of synaptic and neurotransmission release-related genes (VAMP2, SYT1 and SYT11) and genes encoding microtubule proteins within the axons (TUBA1C and TUBB4A) in plaque-AsymAD versus plaque-AD. The gene discussed is TUBB4A; the disease is Alzheimer disease.