Interestingly, pathways related with endocytosis (clathrin-mediated endocytosis, cargo recognition for clathrin-mediated endocytosis, transferrin endocytosis and recycling), autophagy (autophagy, macroautophagy, selective autophagy, chaperone mediated autophagy) and phagocytosis (regulation of actin dynamics for phagocytic cup formation, response of Mtb to phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis) were upregulated more than four times in the amyloid plaque microenvironment of plaque-AsymAD MFGs when compare with plaque-AD MFGs (Bold pathways in Supplementary Excel 2). This evidence concerns the gene TF and Alzheimer disease.