MAPT and Alzheimer disease: Our findings revealed that in the AsymAD MFGs, regardless of the type of plaque, there was a dramatic decrease in NP-tau within the plaque microenvironment in comparison with that in the AD MFGs (Fig. 1f), indicating that although both AsymAD and AD cases exhibit neuritic plaques, the dystrophic neuritic component induced by tau is notably more pronounced in AD cases.