TYROBP and Alzheimer disease: The authors also reported higher levels of the microglial phagocytic complex TREM2/DAP12 in Aβ amyloid plaques in NDAN than in those in AD, concluding that microglia surrounding Aβ plaques in NDAN are hyperactive and more effectively recognize damaged synapses with greater phagocytic capacity than microglia in AD [27].