LOX and neoplasm: To verify LOX expression in our iCCA orthotopic model, we performed IHC analysis with URCCA4.3 tumors, which also demonstrated significantly elevated protein levels that mirrored the expression patterns observed in the malignant epithelium and tumor stroma of KPPC iCCA tumors (Figure 3A, Supplemental Figure S8A, http://links.lww.com/HC9/A993).