LOX and pancreatic ductal adenocarcinoma: ,43 In fact, pan-LOX inhibition with PXS-5505 has recently been shown to alter the highly desmoplastic TME of the KrasG12D/+; Trp53R172H/+; P48-Cre pancreatic ductal adenocarcinoma model,24 rendering it susceptible to chemotherapy and providing insight into its potential therapeutic benefit.