LOX and neoplasm: Quantification of IHC staining showed that CCA tumors expressed significantly higher levels of LOX isoform compared to normal liver, irrespective of tumor subtype (Figure 1B, supplemental methods, Supplemental Figure S2B, http://links.lww.com/HC9/A993) with 51.5% of LOX expression localized to the biliary epithelium compared to 36.4% in the surrounding stroma (Figure 1C, Supplemental Figure S2C, http://links.lww.com/HC9/A993).