PDGFB and arteriovenous hemangioma/malformation: Congruently, aktΔ/Δ mutants at 48 hpf were able to maintain normal circulatory blood flow as the expression of the hemodynamics-sensing genes klf2, pdgfb and cxcr4 (Stratman et al., 2020) were similar to WT at this stage (Fig. S2D), suggesting that the capacity of aktΔ/Δ endothelial cells to respond to blood flow hemodynamics might resolve early arteriovenous malformations (Corti et al., 2011).