MMP2 and glioblastoma: Moreover, a glioblastoma CoC proved effective in investigating the targeting efficacy of resveratrol (Res), an anti‐invasion agent, and combinations of Res and temozolomide (TMZ), where combinations of Res and TMZ were found to be more efficient in suppressing tumor invasion and proliferation by reducing MMP‐2 expression.[94] Similar to the previous study, the exact targeting mechanism is unclear, and further research is needed to better understand them.[94] Future animal studies can further validate these results.