AFP can be used to target metastatic cancer in the liver, in addition to gamma‐glutamyl transpeptidase (γ‐GT) and alkaline phosphatase (ALP).[69] Later studies expanded upon this to develop a 4‐organ MoC platform investigating lung cancer metastasis to the brain, bone, and liver.[247] The platform effectively recapitulated cancer cell migration and colonization at distant organs, as demonstrated by the over‐expression of AFP, RANKL, and CXCR4 protein in liver, bone, and brain cells. Here, TNFSF11 is linked to cancer.