MKI67 and cancer: For example, the endothelial invasion mechanism of colorectal cancer was modeled in a circular 3D microfluidic CoC.[227] The genetic markers Ki‐67, MMP‐1, and Caspase‐3 were effectively recapitulated and their response to treatment with gemcitabine (GEM) was studied.[227] The effective CoC design shows great potential in developing and testing cancer therapies targeting genetic markers.[278, 283, 284]