VIM and cancer: It also revealed EMT activation upon inducing αB‐Crystallin (CRYAB) overexpression.[306] Similarly, a multichannel, 3D NSCLC CoC identified vimentin overexpression as a key indicator of EMT activation and cancer metastasis; EMT was further enhanced under dynamic flow shear stresses generally observed in vivo and successfully recapitulated in the lung cancer OoC.[304] Meanwhile, Aref et al.