EGFR and adenocarcinoma: EGFR, VEGF, interleukin‐6 (IL‐6), IL‐8, and c‐MET proteins are all overexpressed in NSCLC adenocarcinomas; however, EGFR expression is downregulated, and resistance to TKI therapy increases in tumors exposed to mechanical stress caused by breathing.[208] These findings can open new research paths in designing drugs targeting NSCLC tumors by considering the effects of breathing on tumor growth.