Here, a significant TNFR2high cluster (CD3+ CD4+ TNFR2highPD-1low) was increased in SF conventional T cells, suggesting TNFR2, glutamine catabolism and glycolysis could be a potential target in the JIA joint to restore the immunoregulatory balance. This evidence concerns the gene TNFRSF1B and juvenile idiopathic arthritis.