Cluster 15, which encompassed both intermediate (CD16intermediateCD14+) and classical (CD16−CD14+) monocytes (Fig. 2D), was reduced in SF (32.8 ± 4.6% of SF CD11c+ cells) compared to HC and JIA PB (70.7 ± 1.7%, 56.9 ± 1.9%, respectively, P < 0.0001). Here, ITGAX is linked to juvenile idiopathic arthritis.