ITGAX and juvenile idiopathic arthritis: Whilst there was no statistical difference in the frequency of intermediate monocytes in the inflamed joint compared to PB, CD16−CD14+ monocytes were significantly reduced in number (39.5 ± 4.7% CD16−CD14+ of SF CD11c+ cells vs HC PB 72.9 ± 2.2% or JIA PB 59.3 ± 2.0%, P < 0.0001, Fig. 2E), thus driving reduction of cluster 15 in SF.