DNMT3A and neuroblastoma: This protein stabilizes MYCN, resulting in very similar outcomes as MYCN-amplified cases.59,60 Additional genes, encoding chromatin remodeling factors, have also been involved in NB development including chromodomain helicase DNNA-binding protein (CHD5), AT-Rich Interaction Domain 1A/1B (ARID1A/ARID1B), Brahma related gene 1 (BRG1), and DNA methyltransferase 3 alpha/beta (DNMT3A/B).61