MYCN and neoplasm: We also showed that inhibition of carnitine/palmitoyl-transferase 1 (CPT1), the rate-limiting enzyme of FAO, reduced proliferation in vitro and tumor growth in vivo.80 Moreover, inhibition of MYCN impaired β-oxidation of fatty acids leading to the accumulation of lipid droplets.98 Tao et al., reported that MYCN amplification promoted fatty acid uptake and biosynthesis due to direct upregulation of the fatty acid transport protein 2 (FATP2).