For these patients, clinicians can adopt a treatment-free/observation strategy as these tumors very often undergo spontaneous remission31 and, in case of tumor growth, surgery with or without chemotherapy is sufficient for complete recovery.32 Patients with asymptomatic stage 4S/MS without hepatomegaly and with non-MYCN-amplified tumors, hyperdiploid, and favorable histology are followed during the initial stages. This evidence concerns the gene MYCN and neoplasm.