The cell surface proteoglycan Glypican-2 (GPC2) is particularly overexpressed in MYCN-amplified NB and has emerged as a novel target for CAR-T cell therapy.154,155 Recently, it was reported that peptide-centric CARs (PC-CARs) against PHOX2B selectively eliminated NB tumors. Here, GPC2 is linked to neuroblastoma.