We found that metabolic reprogramming by MYCN inhibition in MYCN-amplified NB is accompanied by an increase in antioxidant enzymes.80 Additionally, a recent study showed that accumulation of 7-dehydrocholesterol (7-DHC), the substrate of 7-DHC reductase (DHCR7), prevented ferroptosis in NB cells, inducing a resistant phenotype associated with aggressiveness.107 Both mechanisms reveal possible vulnerabilities that could be exploited for therapy. Here, MYCN is linked to neuroblastoma.