Moreover, inhibition of the Rho guanine nucleotide exchange factor 12 (ARHGEF12) by the pharmacological inhibitor Y16 or by shRNA robustly promoted NB differentiation and reduced tumorigeneicity through Ras homolog familiy member A(RhoA)/Rho associated protein kinase (ROCK) signaling.136 Furthermore, the small imipridone molecule ONC201 originally identified as a TRAIL-activating compound, which impairs mitochondrial respiration137,138 resulted in neurite outgrowth in MYCN-amplified cell lines. Here, MYCN is linked to neuroblastoma.