For instance, the overexpression of the paired-related homeobox 1 (PRRX1) transcription factor can forcibly change the state of NB cells in vitro from adrenergic to mesenchymal.21 This plasticity and epigenetic control enable them to adapt to various microenvironmental contexts contributing to shaping tumor heterogeneity. Here, PRRX1 is linked to neuroblastoma.