TH and neuroblastoma: In transgenic mice, MYCN expression in migrating NCCs or sympathetic progenitors under the control of the rat tyrosine hydroxylase (TH) promoter results in NB development resembling human tumors with MYCN amplification.40 Transgenic MYCN expression in additional mouse or zebrafish models also recapitulates NB tumorigenesis, proving its role as an oncogenic driver (Supplementary Table S4).