We examined the dose response of Usp22i‐S02 in LUAD cells and found that Usp22i‐S02 did not inhibit USP22 expression and had little effect on cell viability (Figure S5A,B, Supporting Information).[32] Next, based on natural drug active substances used in tumor therapy, we selected berberine (BBR), an isoquinoline alkaloid found in Coptis chinensis structurally similar to Usp22i‐S02 for further study. Here, USP22 is linked to neoplasm.