Atractylenolide‐I (Att), a sesquiterpene component in Atractylodes macrocephala, can act on the 26S immunoproteasome complex in MSS CRC cells, thereby upregulating the expression of MHC‐I in the cells.[16] Therefore, the combination of Rg1 and Att may promote the infiltration of CTLs into tumor tissues to identify tumor cells by enhancing maturation of DCs and increasing MHC‐I expression in tumor cells. The gene discussed is PPP1R3A; the disease is colorectal carcinoma.