For example, concomitant use of β-blockers, calcium channel blockers, or antiarrhythmics in people with dementia treated with acetylcholinesterase inhibitors (AChEIs) may lead to adverse cardiovascular effects such as arrhythmias, heart block, syncope and prolongation of the QT interval (Wiśniowska et al., 2016; Khatib et al., 2021; Ruangritchankul et al., 2021). The gene discussed is ACHE; the disease is Heart block.