The results showed that RAB42 overexpression is significantly correlated with that of partial immunosuppressive genes (C10orfs54, CD274, IDOI, HAVCR2, IL10, SLAMF7, CD276, TGFB1) and immunostimulatory genes (TNFRSF14, TLR4, TNFSF4, CD40LG, CD27, ICOS, PRF1, GZMA, CCL5, IFNG, BTN3A1, BTN3A2, CXCL10, CXCL9, IL2RA, CD80, TNFRRSF9, ITGB2, CD28, ICAM1, ENTPD1, CD40, TNFRSF4) across various cancer types. The gene discussed is CD27; the disease is cancer.