Western blot analysis showed that the expression of p-PI3K, NLRP3, cleaved caspase-1, GSDMD-NT, mature IL-1β, pro-IL-1β, mature IL-18, pro-IL-18 was significantly increased in the NASH group compared with the NC group, and the expression of p-SHP2 and GSDMD-FL was decreased. The gene discussed is PTPN11; the disease is metabolic dysfunction-associated steatohepatitis.