Moreover, Pleomorphic adenoma gene like-2 (PLAGL2) facilitated bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling, and its proproliferative and prometastatic effects were negated by the RhoA inhibitor simvastatin (Chen et al., 2023). This evidence concerns the gene RACGAP1 and urinary bladder cancer.