The phosphoinositide 3-kinase/Protein kinase B (PI3K/Akt) signaling pathway, an inflammatory pathway implicated in severe kidney injury and indirect modulation of uric acid excretion, can be inhibited by Plantago to ameliorate nephropathy and enhance uric acid excretion (Dragos et al., 2020; Santos et al., 2020; Zhao et al., 2020). This evidence concerns the gene AKT1 and Nephropathy.