AKT1 and Disorder of lipid metabolism: Previous studies have shown that Plantago extract improves lipid accumulation in high-fat diet-induced obese mice (Yang et al., 2017), while another study demonstrated that Plantago accelerates lipolysis through regulation of lipid metabolism disorders in a mouse model of hyperuricemia induced by potassium oxybate gavage; additionally, anti-hyperuricemic effects were observed through downregulation of URAT1 expression and inhibition of the PI3K/Akt inflammatory pathway (Yang et al., 2021).