Previously, it has been shown that apigenin can reduce serum uric acid levels, decrease the levels of GLUT9 and URAT1 transport proteins, increase the levels of OAT1 transport proteins, and inhibit the JAK2/STAS3 signaling pathway in a mouse model of acute hyperuricemia induced by potassium oxybate and Hypoxanthine, thus exerting a therapeutic effect on hyperuricemia (Liu et al., 2022). Here, PROS1 is linked to hyperuricemia.