Meanwhile, LEO (7.5, 15, and 30 mg/kg/d for 42 days) could inhibit myocardial fibrosis and decrease Nox4 expression, ROS and NF-κB activation, and plasma MMP-2 activity in post-MI rats (Liu et al., 2013, 4). Here, NFKB1 is linked to myocardial infarction.