However, LEO (20 and 40 mg/kg/d for 91 days) was able to increase fibrous cap thickness and collagen content to enhance plaque stability and prevent stroke and myocardial infarction, which is mediated by regulating the balance of the NOS-NO system to maintain vascular homeostasis and inhibiting inflammatory response through NF-κB in ApoE−/−mice (Ning et al., 2020). Here, NFKB1 is linked to myocardial infarction.