TNF and neurodegenerative disease: Although the specific mechanism of IL-17A in neurodegenerative diseases is still controversial, it is generally accepted that IL-17A causes diseases by activating glial cells; (iii) TNF signaling pathway: the TNF signaling pathway plays an essential role in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, and modulation of immune responses and induction of inflammation.