Interestingly, rescued genes upregulated in both cortex and hippocampus included genes related to DS and Alzheimer disease, such as App (Tosh et al., 2021), Ets2 (Helguera et al., 2005), Bace2 (Alić et al., 2021), and Olig2 (Choong et al., 2015). The gene discussed is BACE2; the disease is early-onset autosomal dominant Alzheimer disease.