Furthermore, enriched KEGG pathways in cortex were found to be related to: (i) Alzheimer’s disease; (ii) Il-17 signaling pathway: several studies have suggested a critical role for the interleukin-17A (IL-17A) cytokine family in human inflammatory or autoimmune diseases and neurodegenerative diseases (Chen et al., 2020). This evidence concerns the gene IL17A and early-onset autosomal dominant Alzheimer disease.