ADAM8 and systemic lupus erythematosus: Since SLE and SSc patients showed differences in the percentage of ADAM8(+) neutrophils (Figure 3A), we then computed sADAM8/% ADAM8(+) neutrophil ratio for each patient and found lower levels in SSc when compared to SLE patients, with an optimal cut-off value of 21.1 (Figure 8A).