In SSc patients, we have observed that higher serum levels of PSGL-1 were associated with the presence of ILD and anti-Scl70 antibodies, whereas lower serum levels were associated with anti-centromere antibodies, and higher sE-selectin levels were associated with the presence of ILD and PAH, in line with previous reports (41, 54). This evidence concerns the gene SELPLG and pulmonary arterial hypertension.