1. Neoadjuvant intra-tumoral influenza vaccine:i) down regulates CXCL1, CXCL2, CXCL8 and CXCR2,ii) downregulates genes related to neutrophils and its activation, iii) upregulates the transcription of Th1, CD8, TILs, cytotoxic function, CD8+T cell infiltration, iv) increases CD8/neutrophil ratio, down regulates FOXP3 (spatial IHC).2. Anti-IL-8, a monoclonal antibody HuMax-IL8 reduced serum IL8 and showed safety and stable disease in phase 1 trial. Here, CXCL2 is linked to influenza.