CD8A and colorectal carcinoma: 1. MMRp differs from anti-tumor hub of MMRd characterized by CXCR3L+ multicellular foci, ISG+myeloid and malignant cells, activated T cells, CXCL13+T cells, IFN-γ+T cells, CXCL9–11, and upregulated CXCR3 in activated T cells and in DC).2. MMRp-R type CRC at base line, CXCL13 high expression, PD1+CD8+ IFN-γ+TILs with TH17 low are responsive to ICB and resemble MMRd TILs