Analysis of TCGA data, tissue microarray, RNA-Seq and preclinical mice experiments using MC38 (MDSC rich), CT26 (immune inflamed, MMRp), and CD34/immune reconstituted humanized immune CRC xenograft mice models deciphered that m6A reader YTHDF1 had an inverse correlation with IFN-γ gene signature. The gene discussed is IFNG; the disease is colorectal carcinoma.