CD4 and colorectal carcinoma: 1. In CRCR, CCR5-CCL5 is associated with CMS 1 and CMS 4, high TMB, and high TILs, TIS, and low PDL-1 level.2. High CCR5 and CCL5 transcripts maintain high ratio with M2 and Tregs.3 In both MMRp and MMRd, F. neuleatum derived succinate reduces CCL5, CXCL10, IFN-β, desensitize CD8 to ICB4. In CRC-L, MDSC via CXCL 9 and 10 triggers T cell movement in invasive margin, CCL5+CD4 and CD8 cells induces tumor-growth via macrophage MMP.