Apoptotic cancer cells release CXCL8, which attracts neutrophils into the tumor, interacts with macrophages and regulates the immune microenvironment of CRC.IL-8 regulates tumor stem cells (CSC) in colon and lung cancer cells via glucose transporter protein 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT) induced glucoramidic (O-GlcNAc) modification Sample Properties (51). The gene discussed is CXCL8; the disease is cancer.