AGPAT4 and colorectal carcinoma: The axis between 1-acylglycerol-3-phosphate O-acyltransferase 4 (Agpat4) and lysophosphatidic acid (LPA) in CRC cells modulates p38/p65 signaling-dependent macrophage M1 polarization, promotes T-cell activation, and inhibits CRC progression (42).