↑ Thrombus size and weight, Cit-H3, HMGB-1, and uric acid, αSMA, and fibronectin expression in the vein wall; ↓ thrombus collagen, neovascularization, free fibrinogen, CD31, VE-cadherin expression, IFN-α, IL-1α, IL-18, and IL-2 levels in the vein wall. This evidence concerns the gene HMGB1 and thrombotic disease.