Moreover, membrane particles (MPs) derived from IFN-γ stimulated MSCs have been found to increase mRNA expression of Programmed Cell Death Ligand 1 (PD-L1) in monocytes as well as the percentage of anti-inflammatory PDL-1 and CD90-positive monocytes suggesting potential use for MP-based cell-free therapy for immune diseases (106). The gene discussed is CD274; the disease is immune system disorder.