In the context of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren’s syndrome (SS), dysregulated hyperactivation of the AIM2 inflammasome pathway may occur due to the continuous accumulation of self-derived DNA substrates (24–26). The gene discussed is AIM2; the disease is systemic lupus erythematosus.