The canonical pyroptotic pathway, also known as the caspase 1-dependent pathway, involves the activation of inflammasomes such as NLRP3, NLRC4, AIM2, Pyrin, etc. In the molecular pathways of MSU-triggered inflammation, the NLRP3 inflammasome plays a crucial role in the innate immune response associated with gout. The gene discussed is AIM2; the disease is gout.