Therefore, in this study, we evaluated the expression of AIM2, Caspase 1, and GSDMD in PBMCs of patients diagnosed with AGA and AHU, estimated the levels of the inflammatory cytokines IL-1β and IL-18 in serum, hope to provide new insights into the involvement of the AIM2 mediated pyroptosis pathway in the development of AGA and strategies for treating gout. This evidence concerns the gene IL1B and gout.