Therefore, in this study, we evaluated the expression of AIM2, Caspase 1, and GSDMD in PBMCs of patients diagnosed with AGA and AHU, estimated the levels of the inflammatory cytokines IL-1β and IL-18 in serum, hope to provide new insights into the involvement of the AIM2 mediated pyroptosis pathway in the development of AGA and strategies for treating gout. Here, CASP1 is linked to gout.