Common variable immunodeficiencyHypogammaglobulinemia requiring immunoglobulin therapyAgammaglobulinemia—X-linked or autosomal recessiveHyper-IgM syndromeSevere combined immunodeficiencyWiskott-Aldrich syndromeHyper-IgE syndrome (STAT3 or DOCK8)Any patients with severe-enough immunodeficiency that they require immunoglobulin therapyDiGeorge syndrome (22q deletion syndrome) requiring prophylactic antibioticsHIV with CD4 cell count <50/mm3 within past 6 mo. The gene discussed is STAT3; the disease is Down syndrome.