The overall yield of the secondmethod ranges from 60% to 70%.15,16 Therapeutic functionsof LA have been studied, such as antimicrobial,17,18 tumor inhibition,19,20 and vitamin D receptor modulation.21,22 LA has been reported as a PTP1B inhibitor with an IC50 value of 12.54 μM and 2-fold more selectivity for PTP1B overTCPTP.23 Despite that, few attempts toprepare semisynthetic derivatives have been reported. This evidence concerns the gene PTPN1 and neoplasm.