Sometargets such as free fatty acid receptor 1 (FFAR1), α-glucosidase,peroxisome proliferator-activated receptor-γ (PPARγ),dipeptidyl peptidase-4 (DPP4), sodium–glucose cotransporter2 (SGLT2), aldose reductase (ALR), glycogen phosphorylase (GP), fructose-1,6-bisphosphatase(FBPase), glucagon receptor (GCGr), phosphoenolpyruvate carboxykinase(PEPCK), and protein tyrosine phosphatase 1B (PTP1B) have been identifiedto treat DM.2,3. Here, PTPN1 is linked to diabetes mellitus.