Both KCNQ1 and KCNE1 are reported to be expressed in the brain, where KCNQ1 interacts with KCNE1 (Goldman et al., 2009; Rannals et al., 2016), and there have been several reports that KCNQ1 variants are associated with both LQTS and epilepsy (Goldman et al., 2009; Tiron et al., 2015). Here, KCNQ1 is linked to familial long QT syndrome.