In hepatocytes, c-Myc is essential to drive proliferation during liver regeneration (Zhang et al., 2018; Wang et al., 2022), and overexpression of c-Myc in the liver has been shown to prevent obesity and insulin resistance (Riu et al., 2002; Riu et al., 2003). Here, MYC is linked to obesity due to melanocortin 4 receptor deficiency.