RANKL-OPG signaling is renowned for osteoclastogenesis, activated RANKL/ERK signaling pathway is associated with activation of osteoclasts and subsequent bone loss (Zhang et al., 2022), whilst CDH11 is a key molecule for the activation of osteoblasts, inducing the premetastatic niche for bone colonization of breast cancer (Li et al., 2022). The gene discussed is TNFRSF11B; the disease is breast cancer.