From the analysis, BMP8A was highly correlated with the biomarkers being profound in the process of bone metastasis, especially osteoblastic factors (RUNX2, CDH11 and PDGFB); and osteolytic factors (CTSK, ITGB3 and RANKL), which strongly indicated the promising role of BMP8A in the bone metastasis of BC in TNBC. This evidence concerns the gene TNFSF11 and breast cancer.