In the current study, we examined The Cancer Genome Atlas (TCGA, n = 542) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC, n = 115) Lung adenocarcinoma (LUAD) datasets to view the relationship between lipid metabolism and HMGB1 in NSCLC tumors (Gillette et al., 2020). The gene discussed is HMGB1; the disease is neoplasm.