For each module, we computed correlations between each eigengene and clinical features such as age, disease classification, diarrhea, nausea, vomiting, acid reflux, upper GI hemorrhage, hepatic function impairment, total bilirubin, glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST), lymphocyte infiltration, plasma cell infiltration, neutrophil infiltration, interstitial vasodilation, interstitial edema, monocytes, macrophages, and CD4+ T-cells (Figure 4C). This evidence concerns the gene CD4 and gastroesophageal reflux disease.