Moreover, in vitro experiments have shown that TRIM28 can also stabilize the protein level of MDM2 by promoting the ubiquitination degradation of RLIM, a ubiquitin E3 ligase of MDM2, thereby further downregulating the low expression level of p53 and ultimately promoting the proliferation, migration, and invasion of LC cells (Jin et al., 2021). Here, MDM2 is linked to laryngotracheoesophageal cleft.