TRIM28 and laryngotracheoesophageal cleft: Although Chen et al. found that high TRIM28 expression was associated with increased overall survival in early LC and reduced cell proliferation in model LC cell lines (Chen et al., 2012), another study showed that TRIM28 knockdown inhibited LC cell proliferation, promoted cell apoptosis, and inhibited the growth of subcutaneous LC grafts in mice (Liu et al., 2018).