Many clinical perspective examines the evidence and implications of numerous inflammatory processes that have been recognized in the tears of keratoconus patients, as well as some inflammation relevant differences found in the keratoconus cornea, it was significantly increased tear expression of MMP-13, IL-6, IL-17, TNF-α and TNF-β was evident in keratoconus tears. The gene discussed is MMP13; the disease is keratoconus.