Periodontal-disease-producing pathogens can synthesize inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and interleukin-1 family (IL-1), which results in inflammation-triggering vascular endothelial damage and when entering the blood instigates systemic inflammation [44,129]. This evidence concerns the gene TNF and inflammatory response.