Suppression of mitochondrial biogenesis: HIF-1α represses the expression of essential regulators of mitochondrial biogenesis, such as PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), which is an example of inhibiting choroid metabolic syndrome (CMS) from forming new structures [18]. The gene discussed is PPARGC1A; the disease is congenital myasthenic syndrome.