We presented a case of a 52-year-old male patient with amiodarone-induced LQTS, which led to TdP tachycardia with rapid conversion to ventricular fibrillation who needed cardiac resuscitation. This case reiterates the importance of remembering that anti-arrhythmics, particularly class III (potassium channel blockers), are also pro-arrhythmic with the possibility of immediate fatal consequences. The gene discussed is KCNA3; the disease is ventricular fibrillation.