The study compared visual and digital assessment of Ezrin expression in colorectal cancer tissues, finding significantly higher Ezrin levels in cancerous tissues compared to adjacent normal mucosa. Ezrin was expressed in 92.2% of CRC cases, correlating with tumor grade. Results showed a strong correlation (R = 0.868) between subjective and quantitative methods, suggesting digital pathology enhances diagnostic accuracy and reliability. The gene discussed is EZR; the disease is neoplasm.