miR-148a, which is enriched in MSC-derived EVs, can target KLF6 to reprogram the proinflammatory phenotype of macrophages to the anti-inflammatory phenotype by inhibiting the signal transducer and activator of transcription 3 (STAT3) pathway and consequently can alleviate liver fibrosis [25]. Here, STAT3 is linked to Hepatic fibrosis.