For example, DE-NMRGs might influence the development and progression of GC through various pathways, including NAD biosynthetic process, nicotinamide nucleotide biosynthetic process, positive regulation of immune response to tumor cell, positive regulation of immune effector process, JAK-STAT signaling pathway, nicotinate and nicotinamide metabolism and nucleotide metabolism, etc. (Figs. 1D and 1E, Tables S3 and S4). This evidence concerns the gene SOAT1 and neoplasm.