The oxidative stress leading to intracellular accumulation of hyperphosphorylated tau protein as neurofibrillary tangle (NFT) and extracellular deposition of beta-amyloid (Aβ) plaque at the hippocampus and other parts of the brain are the pathological features of Alzheimer’s disease (AD) (Rao et al. 2020; Huang et al. 2016; Chu 2012). The gene discussed is MAPT; the disease is Alzheimer disease.