AMD is associated with chronic inflammation, and the eyes of AMD patients show high expression of inflammation/immunity-related factors, including IL-17 receptor C, IL-17F, IL-6, etc. The retina and choroid can recruit numerous macrophages and microglia, which are distributed among the non-immune cells (RPE and Müller cells), and are involved in disease development. The gene discussed is IL17F; the disease is age-related macular degeneration.