SH2D3C and COVID-19: PLpro exhibits specificity towards a distinct sequence motif (LXGG tetrapeptide) situated among various viral proteins, cleaving the replicase polyproteins at their N‐termini to release essential individual NSPs, including nsp1, nsp2, and nsp3, vital for viral replication.[10, 11] Moreover, PLpro contributes to the evasion of the host‘s antiviral immune response by deubiquitinating and deISGylating host cell proteins.[12] Consequently, the inhibition of PLpro emerges as a promising therapeutic approach for COVID‐19 patients, given its pivotal role in viral replication and immune evasion.