SH2D3C and COVID-19: SARS‐CoV‐2, the causative agent of COVID‐19, possesses a single‐stranded, positive‐sense RNA genome encompassing at least ten open reading frames (ORFs).[7] The primary ORF, known as ORF1ab, constitutes approximately two‐thirds of the viral genome and encodes two pivotal overlapping polyproteins, pp1a and pp1ab.[7] These polyproteins play indispensable roles in viral replication and transcription, undergoing cleavage by virally encoded cysteine proteases to yield 16 non‐structural proteins (NSPs).[7, 8, 9] One of these proteases, papain‐like protease (PLpro), is encoded within NSP3.