In addition to the intranasal delivery of exogenous oxytocin, endogenous oxytocin can be elevated in different ways, including social and environmental enrichment,[56] and these factors are also reported to attenuate the nigrostriatal lesioning in the PD model.[66, 67] In our study, chemogenetic activation of PVN oxytocin neurons did not significantly attenuate striatum TH reduction in the PD model, and we speculate that the short‐term acute elevation of oxytocin level by chemogenetic activation may be not sufficient to protect nigrostriatal DA signal. This evidence concerns the gene TH and Parkinson disease.