However, in the MPTP‐induced PD model, striatum TH expression in the Oxt‐Cre; DTR mice with DT injection (Cre+ & DT+ & MPTP group), but not in the Oxt‐Cre negative; DTR mice with DT injection (Cre‐ & DT+ & MPTP group), was significantly less than TH expression in the Oxt‐Cre; DTR mice with saline injection (Cre+ & DT‐ & MPTP group) (TH change relative to the Cre+ & DT‐ & MPTP group, Cre+ & DT+ & MPTP group: 58.16 ± 5.67%; Cre‐ & DT+ & MPTP group: 93.20 ± 10.80%. The gene discussed is TH; the disease is Parkinson disease.