In this study, heatmap analysis results showed that LYZ can downregulate the expression of major genes involved in PANoptosis in an in vitro GMEC mastitis model (Figure 1e), and the in vivo results demonstrated that high expression of LYZ can alleviate BMB damage in GED goats; however, the detailed mechanism by which mastitis leads to BMB damage is not clear. The gene discussed is LYZ; the disease is mastitis.