Recently, the integrity and permeability of the BMB have emerged as crucial considerations in mastitis research because alleviating BMB damage can impede the spread of mastitis.[7, 24] This study proved that GED goats with high LYZ expression could alleviate BMB damage, effectively protect the integrity of the structure within the mammary gland, and maintain the dynamic balance of inflammatory factors, preventing the further mastitis expansion. Here, LYZ is linked to mastitis.