Consistent with our study, relevant studies indicated that the anti‐sp100‐positive patients with PBC who had an increased frequency of DRB1*03:01 suffered from cirrhosis more frequently compared to anti‐sp100‐negative patients (Mytilinaiou et al., 2012; Tana et al., 2015; Wang et al., 2019). This evidence concerns the gene HLA-DRB1 and Cirrhosis.