Besides its role in blood pressure regulation, the KCa3.1 channel modulates ion transport in epithelial cells (Singh et al., 2001), renal fibroblast proliferation and fibrogenesis (Grgic et al., 2009), and is a key cellular effector in several life-threatening diseases such as atherosclerosis, restenosis, and traumatic injury-induced edema (Kohler et al., 2003; Tharp and Bowles, 2009; Toyama et al., 2008). Here, KCNN4 is linked to atherosclerosis.